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Taylor & Francis Group,
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One of the major recent discoveries in molecular and cellular biology is that small double-stranded RNA molecules selectively turn off gene expression in all types of cell, a phenomenon known as RNA silencing. This discovery led to the development of RNA interference (known as RNAi) as a powerful research tool in the functional study of individual genes and their products, and in functional genomics. In RNAi, specific small double-stranded RNA molecules (small interfering RNAs or siRNAs) are introduced into cells to selectively silence certain genes.

RNAi covers the basic concepts and mechanisms of RNAi, transfection of cells with siRNAs, the design and validation of RNAi reagents, RNAi techniques in different organisms, large-scale RNAi screening, applications of RNAi in drug discovery, and potential uses of RNAi as a therapeutic agent. A key feature of RNAi is the highlighting of the pitfalls that can occur and how to minimize them. The book also contains a complete list of abbreviations.

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Grouped Work ID 806e07e9-3ecd-98e3-e2a0-3a8eeb9c9de3
full_title rnai
author martin latterich
grouping_category book
lastUpdate 2017-08-14 05:04:19AM

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author2-role , (OCoLC)229910273, .b1296199107-06-1601-25-11, 0203967216 (electronic bk.), 138 p. :ill. (some col.) ;25 cm., 2008 A-121, 5214609, 572.8/8, 92QYMA7, 9780203967218 (electronic bk.), BIOS advanced methods., Electronic books., Electronic reproduction.Boulder, Colo. :NetLibrary,2008.Available via World Wide Web.Access may be limited to NetLibrary affiliated libraries.This edition published in the Taylor & Francis e-Library, 2007., English qEnglish., Includes bibliographical references and index., LDR63.1 20090105144106 EBKSLDR63.1 20090105144106 EBKS, MAIN, Methods in RNA interference / Martin Latterich and Dalia Halawani -- RNAi regent design / Bernd Jagla and Nathalie Aulner -- RNAi a chemical perspective / Ouathek Ouerfelli -- Validation of RNAi / Nathalie Aulner and Bernd Jagla -- RNAi libraries in dissecting molecular pathways of the human cell / Cheryl Eifert, Antonis Kourtidis and Douglas S. Conklin -- High-throughput RNAi in caenorhabditis elegans from molecular phenotypes to pathway analysis / Sarah Jenna and Eric Chevet -- RNAi in xenopus laevis / Adrianna L. Stromme and Craig A. Mandato -- Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques / Jenni Huusko ... [et al.] -- RNAi in fungi / Hitoshi Nakayashiki., N$TN$T, NetLibrary, Inc., New York, NY :Taylor & Francis Group,c2008., OCLC Holdings Updated 20110802, Original, QP623.5.S63R65 2008eb, QU 475R627 2008, RNA interference., RNAiMartin Latterich, editor., q01-25-11mz-, qBibliographies., qBook., qComputerFiles., qSoftware., qeBook.
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record_details external_econtent:ils:.b12961991|eBook|eBook||English|Taylor & Francis Group,|c2008.|138 p. : ill. (some col.) ; 25 cm.
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series BIOS advanced methods
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title_display RNAi
title_full RNAi [electronic resource] / Martin Latterich, editor
title_short RNAi