RNAi

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Publisher:
Taylor & Francis Group,
Pub. Date:
c2008.
Language:
English
Description

One of the major recent discoveries in molecular and cellular biology is that small double-stranded RNA molecules selectively turn off gene expression in all types of cell, a phenomenon known as RNA silencing. This discovery led to the development of RNA interference (known as RNAi) as a powerful research tool in the functional study of individual genes and their products, and in functional genomics. In RNAi, specific small double-stranded RNA molecules (small interfering RNAs or siRNAs) are introduced into cells to selectively silence certain genes.

RNAi covers the basic concepts and mechanisms of RNAi, transfection of cells with siRNAs, the design and validation of RNAi reagents, RNAi techniques in different organisms, large-scale RNAi screening, applications of RNAi in drug discovery, and potential uses of RNAi as a therapeutic agent. A key feature of RNAi is the highlighting of the pitfalls that can occur and how to minimize them. The book also contains a complete list of abbreviations.

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ISBN:
9780203967218
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Grouped Work ID 806e07e9-3ecd-98e3-e2a0-3a8eeb9c9de3
full_title rnai
author martin latterich
grouping_category book
lastUpdate 2017-06-24 11:03:20AM

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author_additional Martin Latterich, editor.
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physical 138 p. : ill. (some col.) ; 25 cm.
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series BIOS advanced methods
series2 BIOS advanced methods
series_with_volume BIOS advanced methods
table_of_contents Methods in RNA interference / Martin Latterich and Dalia Halawani -- RNAi regent design / Bernd Jagla and Nathalie Aulner -- RNAi a chemical perspective / Ouathek Ouerfelli -- Validation of RNAi / Nathalie Aulner and Bernd Jagla -- RNAi libraries in dissecting molecular pathways of the human cell / Cheryl Eifert, Antonis Kourtidis and Douglas S. Conklin -- High-throughput RNAi in caenorhabditis elegans from molecular phenotypes to pathway analysis / Sarah Jenna and Eric Chevet -- RNAi in xenopus laevis / Adrianna L. Stromme and Craig A. Mandato -- Generation of transgenic and knockdown mice with lentiviral vectors and RNAi techniques / Jenni Huusko ... [et al.] -- RNAi in fungi / Hitoshi Nakayashiki.
target_audience Other
target_audience_full Other
title RNAi
title_alt RNA interference
title_display RNAi
title_full RNAi [electronic resource] / Martin Latterich, editor
title_short RNAi
title_sort rnai