Protozoans in macrophages

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Landes Bioscience,
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Using as a theme the encounter between protozoan parasites and macrophages, this volume brings together cell biologists, immunologists and protozoologists to review current developments in this broad and dynamic research area. Discussed are ways protozoans establish their intracellular niche, how they activate macrophage effector functions, what these functions are, and means by which several protozoans subvert macrophage activity. What emerges is a picture of the macrophage as a key cell type in the host response to protozoan infection. How these cells respond, and how their responses can be subverted, are likely to be critical determinants in the outcome of protozoan infection.Millions of lives are lost every year to protozoan infections, most importantly those caused by Plasmodium, but also Trypanosoma and Leishmania spp. Other protozoans, such as Toxoplasma, are so exquisitely adapted to their host that they rarely cause disease, except during host immunodeficiency. We hope that by working towards an understanding of the biology of protozoans in macrophages we will ultimately be capable of treating and preventing disease and mortality caused by this major class of microbial pathogens.
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full_title protozoans in macrophages
author eric y denkers ricardo t gazzinelli
grouping_category book
lastUpdate 2017-08-14 05:04:35AM

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table_of_contents Avoidance of innate immune mechanisms by the protozoan parasite, Leishmania spp / David M. Mosser and Suzanne A. Miles -- Survival strategies of Toxoplasma gondii : interference with regulatory and effector functions of macrophages / Carsten G.K. Luder -- Targeting SHP-1 to prevent macrophage activation promotes leishmania pathogenesis / Devki Nandan and Neil E. Reiner -- Negative signaling and modulation of macrophage function in Trypanosoma cruzi infection / Flavia L. Ribeiro-Gomes, Marcela F. Lopes and George A. DosReis -- Effector functions of macrophages in plasmodium parasite infections / Mariela Segura ... [et al.] -- Innate control of Toxoplasma gondii through macrophage-based effector mechanisms / Gregory A. Taylor -- Phagocyte effector functions against leishmania parasites / Christian Bogdan -- Effector mechanisms of macrophages infected with Trypanosoma cruzi / Fredy R.S. Gutierrez., Invasion and intracellular survival by Toxoplasma / L. David Sibley ... [et al.] -- Macrophages, alternative niches for intracellular growth of Trypanosoma cruzi / Julio Scharfstein and Marcos Andre Vannier dos Santos -- Macrophage-leishmania interactions : complexities and uncertainties from the study of leishmaniasis in vivo / Paul M. Kaye -- Innate recognition, cell signaling and pro-inflammatory response during infection with Trypanosoma cruzi / Catherine Ropert and Ricardo T. Gazzinelli -- Modulation of positive signaling and proinflammatory responses by hemozoin, a plasmodium metabolic waste / Martin Olivier and Maritza Jaramillo -- Pro-inflammatory responses and cell signaling during malaria infection : the parasite glycosylphosphatidylinositol ligand / D. Channe Gowda -- Pro-inflammatory responses in macrophages during Toxoplasma gondii infection / Katherine S. Masek and Christopher A. Hunter -- Down-modulation of proinflammatory signal transduction in Toxoplasma gondii-infected macrophages / Barbara A. Butcher ... [et al.].
target_audience Other
target_audience_full Other
title Protozoans in macrophages
title_display Protozoans in macrophages
title_full Protozoans in macrophages [electronic resource] / [edited by] Eric Y. Denkers, Ricardo T. Gazzinelli
title_short Protozoans in macrophages
title_sort protozoans in macrophages