Neurovascular medicine: pursuing cellular longevity for healthy aging

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Publisher:
Oxford University Press,
Pub. Date:
2009.
Language:
English
Description
Disorders of the nervous and vascular systems continue to burden the planet's population not only with increasing morbidity and mortality, but also with a significant financial drain through increasing medical care costs coupled to a progressive loss in economic productivity. For example, more than 500 million individuals suffer from nervous and vascular system disorders in the world that comprise both acute and chronic degenerative diseases such as hypertension, cardiac insufficiency, diabetes mellitus, stroke, traumatic brain injury, and Alzheimer's disease. Given the vulnerability of the nervous and vascular systems, identifying the cellular pathways that determine cellular function, injury, and longevity may significantly assist in the development of therapeutic strategies to either prevent or at least reduce disability from crippling degenerative disorders. With this objective, Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging is intended to offer unique insights into the cellular and molecular pathways that can govern neuronal, vascular, and inflammatory cell function and provide a platform for investigative perspectives that employ novel "bench to bedside" strategies from internationally recognized scientific leaders. In light of the significant and multifaceted role neuronal, vascular, and inflammatory cells play during degenerative disorders, novel studies that elucidate the role of these cells may greatly further our understanding of disease mechanisms for the development of targeted treatments for a wide spectrum of diseases. The authors of this monograph strive to lay the course for the continued progression of innovative investigations and especially those that examine previously unexplored pathways of cell biology with new avenues of study for the maintenance of healthy aging and extended cellular longevity.
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ISBN:
9780199716807
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full_title neurovascular medicine pursuing cellular longevity for healthy aging
author kenneth maiese
grouping_category book
lastUpdate 2017-08-14 05:04:51AM

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physical xii, 580 p. : ill. (chiefly col.) ; 29 cm.
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table_of_contents Neuroimmune interactions that operate in the development and progression of inflammatory demyelinating diseases: lessons from pathogenesis of multiple sclerosis / Enrico Fainardi and Massimiliano Castellazzi -- Brain inflammation and the neuronal fate: from neurogenesis to neurodegeneration / Maria Antonietta Ajmone-Cat, Emanuele Cacci, and Luisa Minghetti -- Immunomodulation in the nervous and vascular systems during inflammation and autoimmunity: the role of T regulatory cells / Kokona Chatzantoni and Athanasia Mouzaki -- Alzheimer's disease: is it caused by cerebrovascular dysfunction? / Christian Humpel -- Proteases in [beta]-amyloid metabolism: potential therapeutic targets against Alzheimer's disease / Noureddine Brakch and Mohamed Rholam -- Neurobiology of postischemic recuperation in the aged mammalian brain / Aurel Popa-Wagner ... [et al.] -- Protein misfolding, mitochondrial disturbances, and kynurenines in the pathogenesis of neurodegenerative disorders / Gabriella Gárdián ... [et al.] -- Redox signaling and vascular function / J. Will Langston, Magdalena L. Circu, and Tak Yee Aw -- Gene therapy toward clinical application in the cardiovascular field / Hironori Nakagami, Mariana Kiomy Osako, and Ryuichi Morishita -- Role of advanced glycation end products, oxidative stress, and inflammation in diabetic vascular complications / Sho-Ichi Yamagishi, Takanori Matsui, and Kazuo Nakamura -- Reducing oxidative stress and enhancing neurovascular longevity during diabetes mellitus / Kenneth Maiese, Zhao Zhong Chong, and Faqi Li., Role of prion protein during normal physiology and disease / Adriana Simon Coitinho and Glaucia N.M. Hajj -- Role of protein kinase C and related pathways in vascular smooth muscle contraction and hypertension / Xiaoying Qiao and Raouf A. Khalil -- Brain temperature regulation during normal neural function and neuropathology / Eugene A. Kiyatkin -- Retinal cellular metabolism and its regulation and control / Dao-Yi Yu ... [et al.] -- Cross talk between the autonomic and central nervous systems: mechanistic and therapeutic considerations for neuronal, immune, vascular, and somatic-based diseases / Fuad Lechin and Bertha van der Dijs -- Neurobiology of chronic pain / Min Zhuo -- Physiological effects and disease manifestations of performance-enhancing androgenic-anabolic steroids, growth hormone, and insulin / Michael R. Graham ... [et al.] -- Mesenchymal stem cells and transdifferentiated neurons in cross talk with the tissue microenvironment: implications for translational science / Katarzyna A. Trzaska ... [et al.] -- Motoneurons from human embryonic stem cells: present status and future strategies for their use in regenerative medicine / K.S.Sidhu -- Adult neurogenesis, neuroinflammation, and therapeutic potential of adult neural stem cells / Philippe Taupin -- Glutamatergic signaling in neurogenesis / Noritaka Nakamichi and Yukio Yoneda --
target_audience Other
target_audience_full Other
title Neurovascular medicine pursuing cellular longevity for healthy aging
title_display Neurovascular medicine pursuing cellular longevity for healthy aging
title_full Neurovascular medicine [electronic resource] : pursuing cellular longevity for healthy aging / [edited by] Kenneth Maiese
title_short Neurovascular medicine
title_sort neurovascular medicine pursuing cellular longevity for healthy aging
title_sub pursuing cellular longevity for healthy aging