During a road trip through Chile, boorish American expatriate Jamie and three Chilean brothers plan to set off in search of the prized San Pedro cactus and its promise of unrivaled hallucinations. But during a night's drunken stupor Jamie invites free-spirited fellow American Crystal Fairy along on their psychedelic-driven journey, and before long Crystal's devil-may-care attitude gives them more of an adventure than any of them had bargained for....