Santiago and Eugenio are best friends who run a thriving electronics store together. One day, Eugenio doesn't come to work, and Santiago delays telling anyone while trying to figure out why. Then Laura, Eugenio's wife, shows up to say that Eugenio has disappeared. Perplexed, the two embark on a journey to find him, only to discover that true happiness can sometimes mean losing everything.

A tumultuous but enduring relationship between two men across many years of laughter, heartbreak and rage. It is also the story of real-life best friends who turn their profound connection into a rich, humane and frequently uproarious film about the boundaries, or lack thereof, in all close friendships.