After a fight at school leaves Marcus facing suspension, Marcus's mother takes him and his younger brother, who has Down syndrome, to Puerto Rico to visit relatives they do not remember or have never met, and while there Marcus starts searching for his father, who left their family ten years ago and is somewhere on the island.

Eleven-year-old Lily has trouble leaving her best friend behind and moving to the city when her mother changes jobs, but she makes some very unlikely friends that soon become like family members.

Shawn McDaniel, almost fifteen, cannot speak and has no control over his body due to severe cerebral palsy, but he forms a strong connection with his mother's cousin Debi, who has Down Syndrome, and her dog Rusty.

Fifth grade is not for amateurs, according to Liam. Luckily, he knows that being more than one-third nerd is not cool. Liam lives in the Bay area near San Francisco with his mom and two younger sisters. Dakota is fascinated by science and has a big personality but struggles to make friends; Izzy, a child with Down syndrome, makes friends easily and notices things that go past everyone else. Dad lives across town, but he's over a lot. And then there's...

"When thirteen-year-old amateur entomologist Daisy gets an assignment to 'change the world,' she's determined to help her older brother, Sorrel--who has Down syndrome and adores men's fashion--fulfill his dream of becoming a YouTube celebrity"--

Jamie likes to pretend he's a superhero. With his cape and gadgets, he feels like he can face anything. When his picture is chosen to be shown in Times Square for the NDSS Buddy Walk®, his family travels to New York City to see it. As he makes his way through the loud, busy, unfamiliar city, Jamie discovers that he doesn't have all his special tools. But he soon realizes that it isn't what he wears or the gadgets he uses that make him brave--it's...

Rosie loves Jack. Jack loves Rosie. So when they're split up, Rosie will do anything to find the boy who makes the sun shine in her head. Even run away from home. Even cross London and travel to Brighton alone, though the trains are cancelled and the snow is falling. Even though any girl might find that hard, let alone a girl with Down's syndrome.