Story of General Patton in World War II whose military brilliance was balanced by his inability to deal with the social and political aspects of war, causing him difficulties in his dealings with the War Department.

Susan Murphy gets turned into a giant monster on her wedding day when a meteorite from outer space hits her. She is taken to a secret government compound where she meets a ragtag group of monsters also rounded up over the years. As a last resort, under the guidance of General W.R. Monger, on a desperate order from The President, the motley group of Monsters are called into action to combat the aliens and save the world from imminent destruction.