FBI agent Clarice Starling is assigned to help find a missing woman to save her from a psychopathic serial killer who skins his victims. Clarice attempts to gain a better insight into the twisted mind of the killer by talking to another psychopath Hannibal Lecter, who used to be a respected psychiatrist.

The residents of Haddonfield don't know it yet, but death is coming to their small sleepy town. Sixteen years ago, Michael Myers, a ten year old boy, brutally kills his step father, his elder sister and her boyfriend. Sixteen years later, he escapes from the mental institution he has been placed in and makes his way back to his hometown intent on a murderous rampage. He is pursued by Dr. Sam Loomis who is Michael's doctor and the only one who knows...