A young orphan named Lewis Barnavelt aids his magical uncle in locating a clock with the power to bring about the end of the world.

When middle-schooler Emily Elizabeth meets a magical animal rescuer who gifts her a little, red puppy, she never anticipated waking up to find a giant ten-foot hound in her small New York City apartment. While her single mom is away for business, Emily and her fun but impulsive uncle Casey set out on an adventure that will keep viewers on the edge-of-their-seats as the heroes take a bite out of the Big Apple.