Four friends, all high school teachers, test a theory that they will improve their lives by maintaining a constant level of alcohol in their blood.

Kim and Amy have been best friends since high school but haven't seen each other since Amy moved to the West Coast for grad school. They are reunited on a trip to Jay, Kim's boyfriend's lake house, joined by Jay himself, his stepbrother Alex, and Kim's cousin, Lin. When Amy left for the West Coast, she was in love with Jay, even though she thought it'd never work out because she was fat. Now that things have changed, and they are all here, it's impossible...

Billy and Ray are lifelong best friends and the last two men on Earth. Their survival is largely due to Ray, a brilliant scientist who designed a domed structure with all the systems necessary to sustain life. However, with the fish that provide essential protein dying out, Billy and Ray must find a way to survive.

The highly anticipated sequel follows our four best friends as they take their book dub to Italy for the fun girl's trip they never had. When things go off the rails and secrets are revealed, their relaxing vacation turns into a once-in-a-lifetime cross-country adventure.

Mining the emotional sense memories of their fractured childhoods, Josh and Benny Safdie craft a by turns empathetic and disquieting portrait of parental dysfunction poised between fierce love and terrifying irresponsibility. Manic Manhattan movie theater projectionist Lenny is perhaps the last person who should be raising kids, yet here he is, trying (and failing) to keep it together as his life unravels over the two whirlwind weeks that he has custody...