While Andy's parents are at the hospital with a new baby, leaving Andy and his sister at home with their germaphobic aunt, Andy thinks that Aunt Janet wants him to get rid of his pets.

Eleven-year-old aspiring basketball star and interior designer Lucy Wu is excited about finally having her own bedroom, until she learns that her great-aunt is coming to visit and Lucy will have to share a room with her for several months, shattering her plans for a perfect sixth-grade year.

As a child Great-aunt Alice Rumphius resolved that when she grew up she would go to faraway places, live by the sea in her old age, and do something to make the world more beautiful--and she does all those things, the last being the most difficult of all.